DOI: 10.1073/pnas.95.13.7427. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export

A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export

10.1073/pnas.95.13.7427

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Yeast cells mutated in YRB2 , which encodes a nuclear protein with similarity to other Ran-binding proteins, fail to export nuclear export signal (NES)-containing proteins including HIV Rev out of the nucleus. Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle between the nucleus and the cytoplasm but instead remains inside the nucleus. However, by both biochemical and genetic criteria, Yrb2p interacts with Xpo1p and not with other members of the importin/karyopherin β superfamily. Moreover, the Yrb2p region containing nucleoporin-like FG repeats is important for NES-mediated protein export. Taken together, these data suggest that Yrb2p acts inside the nucleus to mediate the action of Xpo1p in at least one of several nuclear export pathways.

Bibliography

Taura, T., Krebber, H., & Silver, P. A. (1998). A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export. Proceedings of the National Academy of Sciences, 95(13), 7427â7432.

Authors 3

Tetsuya Taura (first)
Heike Krebber (additional)
Pamela A. Silver (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:42 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 4:05 p.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:31 p.m.)
Issued	27 years, 2 months ago (June 23, 1998)
Published	27 years, 2 months ago (June 23, 1998)
Published Online	27 years, 2 months ago (June 23, 1998)
Published Print	27 years, 2 months ago (June 23, 1998)

Funders 0

None

BibTeX

@article{Taura_1998, title={A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.13.7427}, DOI={10.1073/pnas.95.13.7427}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Taura, Tetsuya and Krebber, Heike and Silver, Pamela A.}, year={1998}, month=jun, pages={7427–7432} }

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