DOI: 10.1073/pnas.95.11.6355. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

10.1073/pnas.95.11.6355

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate–early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with the integrin αVβ3and augments growth factor-induced DNA synthesis in the same cell type. In this study, we show that purified CYR61 stimulates directed migration of human microvascular endothelial cells in culture through an αVβ3-dependent pathway and induces neovascularization in rat corneas. Both the chemotactic and angiogenic activities of CYR61 can be blocked by specific anti-CYR61 antibodies. Whereas most human tumor-derived cell lines tested expressCYR61, the gastric adenocarcinoma cell line RF-1 does not. Expression of theCYR61cDNA under the regulation of a constitutive promoter in RF-1 cells significantly enhances the tumorigenicity of these cells as measured by growth in immunodeficient mice, resulting in tumors that are larger and more vascularized than those produced by control RF-1 cells. Taken together, these results identify CYR61 as an angiogenic inducer that can promote tumor growth and vascularization; the results also suggest potential roles for CYR61 in physiologic and pathologic neovascularization.

Bibliography

Babic, A. M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1998). CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proceedings of the National Academy of Sciences, 95(11), 6355â6360.

Authors 4

Alexander M. Babic (first)
Maria L. Kireeva (additional)
Tatiana V. Kolesnikova (additional)
Lester F. Lau (additional)

References 51 Referenced 399

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:26 a.m.)
Indexed	4 minutes ago (Aug. 28, 2025, 11:34 p.m.)
Issued	27 years, 3 months ago (May 26, 1998)
Published	27 years, 3 months ago (May 26, 1998)
Published Online	27 years, 3 months ago (May 26, 1998)
Published Print	27 years, 3 months ago (May 26, 1998)

Funders 0

None

BibTeX

@article{Babic_1998, title={CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.11.6355}, DOI={10.1073/pnas.95.11.6355}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Babic, Alexander M. and Kireeva, Maria L. and Kolesnikova, Tatiana V. and Lau, Lester F.}, year={1998}, month=may, pages={6355–6360} }

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      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}