DOI: 10.1073/pnas.95.1.114. Twenty proteins containing a C-terminal SOCS box form five structural classes

Twenty proteins containing a C-terminal SOCS box form five structural classes

10.1073/pnas.95.1.114

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various means, to negatively regulate cytokine signal transduction. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. By using the SOCS box amino acid sequence consensus, we have searched DNA databases and have identified a further 16 proteins that contain this motif. These proteins fall into five classes based on the protein motifs found N-terminal of the SOCS box. In addition to four new SOCS proteins (SOCS-4 to SOCS-7) containing an SH2 domain and a SOCS box, we describe three new families of proteins that contain either WD-40 repeats (WSB-1 and -2), SPRY domains (SSB-1 to -3) or ankyrin repeats (ASB-1 to -3) N-terminal of the SOCS box. In addition, we show that a class of small GTPases also contains a SOCS box. The expression of representative members of each class of proteins differs markedly, as does the regulation of expression by cytokines. The function of the WSB, SSB, and ASB protein families remains to be determined.

Bibliography

Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., & Nicola, N. A. (1998). Twenty proteins containing a C-terminal SOCS box form fiveâstructuralâclasses. Proceedings of the National Academy of Sciences, 95(1), 114â119.

Authors 10

Douglas J. Hilton (first)
Rachael T. Richardson (additional)
Warren S. Alexander (additional)
Elizabeth M. Viney (additional)
Tracy A. Willson (additional)
Naomi S. Sprigg (additional)
Robyn Starr (additional)
Sandra E. Nicholson (additional)
Donald Metcalf (additional)
Nicos A. Nicola (additional)

References 21 Referenced 603

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J N Ihle, I M Kerr Trends Genet 11, 69–74 (1995). (10.1016/S0168-9525(00)89000-9) / Trends Genet by Ihle J N (1995)
R Starr, T A Willson, E M Viney, L J Murray, J R Rayner, B J Jenkins, T J Gonda, W S Alexander, D Metcalf, N A Nicola, D J Hilton Nature (London) 387, 917–921 (1997). (10.1038/43206) / Nature (London) by Starr R (1997)
T A Endo, M Masuhara, M Yokouchi, R Suzuki, K Mitsui, H Sakamoto, M Ohtsubo, H Misawa, Y Kanekura, A Yoshimura Nature (London) 387, 921–924 (1997). (10.1038/43213) / Nature (London) by Endo T A (1997)
T Naka, M Narazaki, M Hirata, T Matsumoto, S Minamoto, A Aono, N Nishimoto, T Kajita, T Taga, K Yoshizaki, S Akira, T Kishimoto Nature (London) 387, 924–929 (1997). (10.1038/43219) / Nature (London) by Naka T (1997)
A Yoshimura, T Ohkubo, T Kiguchi, N A Jenkins, D J Gilbert, N G Copeland, T Hara, A Miyajima EMBO J 14, 2816–2826 (1995). (10.1002/j.1460-2075.1995.tb07281.x) / EMBO J by Yoshimura A (1995)
S Minamoto, K Ikegame, K Ueno, M Narazaki, T Naka, H Yamamoto, T Matsumoto, M Saito, S Hosoe, T Kishimoto Biochem Biophys Res Commun 237, 79–83 (1997). (10.1006/bbrc.1997.7080) / Biochem Biophys Res Commun by Minamoto S (1997)
A Matsumoto, M Masuhara, K Mitsui, M Yokouchi, M Ohtsubo, H Misawa, A Miyajima, A Yoshimura Blood 89, 3148–3154 (1997). (10.1182/blood.V89.9.3148) / Blood by Matsumoto A (1997)
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T Pawson Adv Cancer Res 64, 87–110 (1994). (10.1016/S0065-230X(08)60835-0) / Adv Cancer Res by Pawson T (1994)
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M Masuhara, H Sakamoto, A Matsumoto, R Suzuki, H Yasukawa, K Mitsui, T Wakioka, S Tanimura, A Sasaki, H Misawa, M Yokouchi, M Ohtsuba, A Yoshimura Biochem Biophys Res Commun 239, 439–446 (1997). (10.1006/bbrc.1997.7484) / Biochem Biophys Res Commun by Masuhara M (1997)
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:42 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 9:38 p.m.)
Indexed	21 hours, 20 minutes ago (Aug. 31, 2025, 6:17 a.m.)
Issued	27 years, 7 months ago (Jan. 6, 1998)
Published	27 years, 7 months ago (Jan. 6, 1998)
Published Online	27 years, 7 months ago (Jan. 6, 1998)
Published Print	27 years, 7 months ago (Jan. 6, 1998)

Funders 0

None

BibTeX

@article{Hilton_1998, title={Twenty proteins containing a C-terminal SOCS box form five structural classes}, volume={95}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.95.1.114}, DOI={10.1073/pnas.95.1.114}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hilton, Douglas J. and Richardson, Rachael T. and Alexander, Warren S. and Viney, Elizabeth M. and Willson, Tracy A. and Sprigg, Naomi S. and Starr, Robyn and Nicholson, Sandra E. and Metcalf, Donald and Nicola, Nicos A.}, year={1998}, month=jan, pages={114–119} }

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        "label": "Publication History"
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    {
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    }
  ]
}