DOI: 10.1073/pnas.94.7.3082. Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos

Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos

10.1073/pnas.94.7.3082

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Establishment of the vertebrate body plan requires a variety of signaling molecules. In a search for tyrosine kinases expressed in early zebrafish embryos, a model system for the study of vertebrate development, we discovered Jak1 kinase to be maternally encoded and the mRNA evenly distributed among the cells of blastula-stage embryos. Injection of RNA-encoding dominant-negative Jak1 kinases reduces a specific cell migration, epiboly, and results in the reduction of goosecoid expression and of anterior structures. This work establishes that, in addition to its role in signal transduction of cytokines in adult tissues, Jak1 kinase has a role in early vertebrate development.

Bibliography

Conway, G., Margoliath, A., Wong-Madden, S., Roberts, R. J., & Gilbert, W. (1997). Jak1 kinase is required for cell migrations and anterior specification in zebrafishâembryos. Proceedings of the National Academy of Sciences, 94(7), 3082â3087.

Authors 5

Greg Conway (first)
Ayelet Margoliath (additional)
Sharon Wong-Madden (additional)
Richard J. Roberts (additional)
Walter Gilbert (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:43 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 9:25 p.m.)
Indexed	2 months ago (June 27, 2025, 9:44 a.m.)
Issued	28 years, 4 months ago (April 1, 1997)
Published	28 years, 4 months ago (April 1, 1997)
Published Online	28 years, 4 months ago (April 1, 1997)
Published Print	28 years, 4 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Conway_1997, title={Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.7.3082}, DOI={10.1073/pnas.94.7.3082}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Conway, Greg and Margoliath, Ayelet and Wong-Madden, Sharon and Roberts, Richard J. and Gilbert, Walter}, year={1997}, month=apr, pages={3082–3087} }

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