DOI: 10.1073/pnas.94.7.2939. Subunit arrangement in the human 20S proteasome

Subunit arrangement in the human 20S proteasome

10.1073/pnas.94.7.2939

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In human 20S proteasomes two copies of each of seven different α-type and seven different β-type subunits are assembled to form a stack of four seven-membered rings, giving the general structure α1–7, β1–7, β1–7, α1–7. By means of immunoelectron microscopy and chemical crosslinking of neighboring subunits, we have determined the positions of the individual subunits in the proteasome. The topography shows that for the trypsin-like, the chymotrypsin-like, and the postglutamyl cleaving activities, the pairs of β type subunits, which are thought to form active sites, are nearest neighbors.

Bibliography

Kopp, F., Hendil, K. B., Dahlmann, B., Kristensen, P., Sobek, A., & Uerkvitz, W. (1997). Subunit arrangement in the human 20Sâproteasome. Proceedings of the National Academy of Sciences, 94(7), 2939â2944.

Authors 6

Friedrich Kopp (first)
Klavs B. Hendil (additional)
Burkhardt Dahlmann (additional)
Poul Kristensen (additional)
Axel Sobek (additional)
Wolfgang Uerkvitz (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:43 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:31 a.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 5:47 a.m.)
Issued	28 years, 5 months ago (April 1, 1997)
Published	28 years, 5 months ago (April 1, 1997)
Published Online	28 years, 5 months ago (April 1, 1997)
Published Print	28 years, 5 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Kopp_1997, title={Subunit arrangement in the human 20S proteasome}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.7.2939}, DOI={10.1073/pnas.94.7.2939}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kopp, Friedrich and Hendil, Klavs B. and Dahlmann, Burkhardt and Kristensen, Poul and Sobek, Axel and Uerkvitz, Wolfgang}, year={1997}, month=apr, pages={2939–2944} }

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