DOI: 10.1073/pnas.94.7.2859. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

10.1073/pnas.94.7.2859

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The sFRPs are not the products of differential splicing of the known frizzled genes. Glycosylphosphatidylinositol-anchored derivatives of sFRP-2 and sFRP-3 produced in transfected human embryonic kidney cells confer cell-surface binding by the Drosophila Wingless protein. These observations suggest that sFRPs may function in vivo to modulate Wnt signaling, or, alternatively, as novel ligands for as yet unidentified receptors.

Bibliography

Rattner, A., Hsieh, J.-C., Smallwood, P. M., Gilbert, D. J., Copeland, N. G., Jenkins, N. A., & Nathans, J. (1997). A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzledâreceptors. Proceedings of the National Academy of Sciences, 94(7), 2859â2863.

Authors 7

Amir Rattner (first)
Jen-Chih Hsieh (additional)
Philip M. Smallwood (additional)
Debra J. Gilbert (additional)
Neil G. Copeland (additional)
Nancy A. Jenkins (additional)
Jeremy Nathans (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 9:25 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 3, 2025, 7:06 p.m.)
Issued	28 years, 4 months ago (April 1, 1997)
Published	28 years, 4 months ago (April 1, 1997)
Published Online	28 years, 4 months ago (April 1, 1997)
Published Print	28 years, 4 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Rattner_1997, title={A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.7.2859}, DOI={10.1073/pnas.94.7.2859}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Rattner, Amir and Hsieh, Jen-Chih and Smallwood, Philip M. and Gilbert, Debra J. and Copeland, Neil G. and Jenkins, Nancy A. and Nathans, Jeremy}, year={1997}, month=apr, pages={2859–2863} }

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