DOI: 10.1073/pnas.94.6.2545. DNA methylation and genetic instability in colorectal cancer cells

DNA methylation and genetic instability in colorectal cancer cells

10.1073/pnas.94.6.2545

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Apparent alterations in DNA methylation have been observed in many cancers, but whether such alterations represent a persistent alteration in the normal methylation process is not known. In this study, we report a striking difference in the expression of exogenously introduced retroviral genes in various colorectal cancer cell lines. Extinguished expression was associated with DNA methylation and could be reversed by treatment with the demethylating agent 5-azacytidine. A striking correlation between genetic instability and methylation capacity suggested that methylation abnormalities may play a role in chromosome segregation processes in cancer cells.

Bibliography

Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997). DNA methylation and genetic instability in colorectal cancerâcells. Proceedings of the National Academy of Sciences, 94(6), 2545â2550.

Authors 3

Christoph Lengauer (first)
Kenneth W. Kinzler (additional)
Bert Vogelstein (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:43 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:17 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 2, 2025, 1:20 a.m.)
Issued	28 years, 5 months ago (March 18, 1997)
Published	28 years, 5 months ago (March 18, 1997)
Published Online	28 years, 5 months ago (March 18, 1997)
Published Print	28 years, 5 months ago (March 18, 1997)

Funders 0

None

BibTeX

@article{Lengauer_1997, title={DNA methylation and genetic instability in colorectal cancer cells}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.6.2545}, DOI={10.1073/pnas.94.6.2545}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lengauer, Christoph and Kinzler, Kenneth W. and Vogelstein, Bert}, year={1997}, month=mar, pages={2545–2550} }

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