DOI: 10.1073/pnas.94.22.12030. A gene spans the pseudoautosomal boundary in mice

A gene spans the pseudoautosomal boundary in mice

10.1073/pnas.94.22.12030

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The X and Y chromosomes of the mouse, like those of other mammals, are heteromorphic over most of their length, but at the distal ends of the chromosomes is a region of sequence identity, the pseudoautosomal region (PAR), where the chromosomes pair and recombine during male meiosis. The point at which the PAR diverges into X- and Y-specific sequences is called the pseudoautosomal boundary. We have completed a genomic walk from the X-specific Amelogenin gene to the PAR. Analysis of this region revealed that the pseudoautosomal boundary of mice is located within an intron of a transcribed gene that encodes a novel RING finger protein. The first three of the exons of the gene are located on the X chromosome whereas the 3′ exons of the gene are located on both X and Y chromosomes. This unusual arrangement may indicate that the gene is in a state of transition from pseudoautosomal to X-unique and provides evidence for a process of attrition of the pseudoautosomal region on the Y chromosome.

Bibliography

Palmer, S., Perry, J., Kipling, D., & Ashworth, A. (1997). A gene spans the pseudoautosomal boundary inâmice. Proceedings of the National Academy of Sciences, 94(22), 12030â12035.

Authors 4

Steve Palmer (first)
Jo Perry (additional)
David Kipling (additional)
Alan Ashworth (additional)

References 31 Referenced 58

10.1007/978-3-642-88178-7
10.1007/BF00274192
10.1016/0168-9525(89)90199-6
10.1038/319291a0
P J Goodfellow, B Pym, T Mohandas, L Shapiro Am J Hum Genet 36, 777–782 (1984). / Am J Hum Genet by Goodfellow P J (1984)
10.1007/BF01233862
10.1006/geno.1993.1135
10.1038/ng0596-83
10.1038/ng0892-333
10.1182/blood.V85.5.1246.bloodjournal8551246
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M Nehls, D Pfeifer, T Boehm Oncogene 9, 2169–2175 (1994). / Oncogene by Nehls M (1994)
10.1073/pnas.85.23.8998
A Ashworth Transcription Factors: A Practical Approach, ed D S Latchman (Oxford Univ. Press, Oxford), pp. 125–142 (1993). / Transcription Factors: A Practical Approach by Ashworth A (1993)
10.1016/0006-291X(92)91366-X
10.1093/hmg/3.4.621
10.1007/BF00355646
10.1073/pnas.93.1.171
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10.1073/pnas.85.8.2733
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10.1016/0092-8674(86)90839-1

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 2 months ago (June 6, 2022, 5:32 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 7, 2025, 4:56 p.m.)
Issued	27 years, 10 months ago (Oct. 28, 1997)
Published	27 years, 10 months ago (Oct. 28, 1997)
Published Online	27 years, 10 months ago (Oct. 28, 1997)
Published Print	27 years, 10 months ago (Oct. 28, 1997)

Funders 0

None

BibTeX

@article{Palmer_1997, title={A gene spans the pseudoautosomal boundary in mice}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.22.12030}, DOI={10.1073/pnas.94.22.12030}, number={22}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Palmer, Steve and Perry, Jo and Kipling, David and Ashworth, Alan}, year={1997}, month=oct, pages={12030–12035} }

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