DOI: 10.1073/pnas.94.2.741. Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

10.1073/pnas.94.2.741

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Dynamic assembly and disassembly of microtubules is essential for cell division, cell movements, and intracellular transport. In the developing nervous system, microtubule dynamics play a fundamental role during neurite outgrowth, elongation, and branching, but the molecular mechanisms involved are unknown. SCG10 is a neuron-specific protein that is membrane-associated and highly enriched in growth cones. Here we show that SCG10 binds to microtubules, inhibits their assembly, and can induce microtubule disassembly. We also show that SCG10 overexpression enhances neurite outgrowth in a stably transfected neuronal cell line. These data identify SCG10 as a key regulator of neurite extension through regulation of microtubule instability.

Bibliography

Riederer, B. M., Pellier, V., Antonsson, B., DiâPaolo, G., Stimpson, S. A., LÃ¼tjens, R., Catsicas, S., & Grenningloh, G. (1997). Regulation of microtubule dynamics by the neuronal growth-associatedâproteinâSCG10. Proceedings of the National Academy of Sciences, 94(2), 741â745.

Authors 8

Beat M. Riederer (first)
Véronique Pellier (additional)
Bruno Antonsson (additional)
Gilbert Di Paolo (additional)
Stephen A. Stimpson (additional)
Robert Lütjens (additional)
Stefan Catsicas (additional)
Gabriele Grenningloh (additional)

References 36 Referenced 169

Goodman C. S. & Shatz C. J. (1993) Cell 72 Suppl. 77–98. (10.1016/S0092-8674(05)80030-3)
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10.1016/0955-0674(94)90119-8

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:43 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:17 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 2:27 a.m.)
Issued	28 years, 7 months ago (Jan. 21, 1997)
Published	28 years, 7 months ago (Jan. 21, 1997)
Published Online	28 years, 7 months ago (Jan. 21, 1997)
Published Print	28 years, 7 months ago (Jan. 21, 1997)

Funders 0

None

BibTeX

@article{Riederer_1997, title={Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.2.741}, DOI={10.1073/pnas.94.2.741}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Riederer, Beat M. and Pellier, Véronique and Antonsson, Bruno and Di Paolo, Gilbert and Stimpson, Stephen A. and Lütjens, Robert and Catsicas, Stefan and Grenningloh, Gabriele}, year={1997}, month=jan, pages={741–745} }

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