DOI: 10.1073/pnas.94.18.9825. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

10.1073/pnas.94.18.9825

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The karyophilic properties of the HIV-1 nucleoprotein complex facilitate infection of nondividing cells such as macrophages and quiescent T lymphocytes, and allow the in vivo delivery of transgenes by HIV-derived retroviral vectors into terminally differentiated cells such as neurons. Although the viral matrix (MA) and Vpr proteins have previously been shown to play important roles in this process, we demonstrate here that integrase, the enzyme responsible for mediating the integration of the viral genome in the host cell chromosome, can suffice to connect the HIV-1 preintegration complex with the cell nuclear import machinery. This novel function of integrase reflects the recognition of an atypical bipartite nuclear localization signal by the importin/karyopherin pathway.

Bibliography

Gallay, P., Hope, T., Chin, D., & Trono, D. (1997). HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherinâpathway. Proceedings of the National Academy of Sciences, 94(18), 9825â9830.

Authors 4

Philippe Gallay (first)
Thomas Hope (additional)
Daniel Chin (additional)
Didier Trono (additional)

References 35 Referenced 404

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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:32 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:04 p.m.)
Indexed	3 weeks, 2 days ago (Aug. 2, 2025, 1:04 a.m.)
Issued	27 years, 11 months ago (Sept. 2, 1997)
Published	27 years, 11 months ago (Sept. 2, 1997)
Published Online	27 years, 11 months ago (Sept. 2, 1997)
Published Print	27 years, 11 months ago (Sept. 2, 1997)

Funders 0

None

BibTeX

@article{Gallay_1997, title={HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.18.9825}, DOI={10.1073/pnas.94.18.9825}, number={18}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Gallay, Philippe and Hope, Thomas and Chin, Daniel and Trono, Didier}, year={1997}, month=sep, pages={9825–9830} }

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