DOI: 10.1073/pnas.94.16.8918. Experience-dependent, asymmetric expansion of hippocampal place fields

Experience-dependent, asymmetric expansion of hippocampal place fields

10.1073/pnas.94.16.8918

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Theories of sequence learning based on temporally asymmetric, Hebbian long-term potentiation predict that during route learning the spatial firing distributions of hippocampal neurons should enlarge in a direction opposite to the animal’s movement. On a route AB, increased synaptic drive from cells representing A would cause cells representing B to fire earlier and more robustly. These effects appeared within a few laps in rats running on closed tracks. This provides indirect evidence for Hebbian synaptic plasticity and a functional explanation for why place cells become directionally selective during route following, namely, to preserve the synaptic asymmetry necessary to encode the sequence direction.

Bibliography

Mehta, M. R., Barnes, C. A., & McNaughton, B. L. (1997). Experience-dependent, asymmetric expansion of hippocampal placeâfields. Proceedings of the National Academy of Sciences, 94(16), 8918â8921.

Authors 3

Mayank R. Mehta (first)
Carol A. Barnes (additional)
Bruce L. McNaughton (additional)

References 20 Referenced 417

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K Blum, L Abbott Int J Neural Syst 6, 25–32 (1995). / Int J Neural Syst by Blum K (1995)
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M Tsodyks, T J Sejnowski Int J Neural Syst 6, 81–86 (1995). / Int J Neural Syst by Tsodyks M (1995)
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J L Kubie, J B Ranck The Neurobiology of the Hippocampus, ed W Seifert (Academic, London), pp. 433–447 (1983). / The Neurobiology of the Hippocampus by Kubie J L (1983)
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10.1523/JNEUROSCI.14-12-07235.1994
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H S Kudrimoti, B L McNaughton, C A Barnes, W E Skaggs Soc Neurosci Abstr 21, 941 (1995). / Soc Neurosci Abstr by Kudrimoti H S (1995)

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:42 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:49 p.m.)
Indexed	3 weeks ago (Aug. 2, 2025, 1:12 a.m.)
Issued	28 years ago (Aug. 5, 1997)
Published	28 years ago (Aug. 5, 1997)
Published Online	28 years ago (Aug. 5, 1997)
Published Print	28 years ago (Aug. 5, 1997)

Funders 0

None

BibTeX

@article{Mehta_1997, title={Experience-dependent, asymmetric expansion of hippocampal place fields}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.16.8918}, DOI={10.1073/pnas.94.16.8918}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mehta, Mayank R. and Barnes, Carol A. and McNaughton, Bruce L.}, year={1997}, month=aug, pages={8918–8921} }

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