DOI: 10.1073/pnas.94.12.6075. Evidence for a mediator cycle at the initiation of transcription

Evidence for a mediator cycle at the initiation of transcription

10.1073/pnas.94.12.6075

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C-terminal domain phosphorylation.

Bibliography

Svejstrup, J. Q., Li, Y., Fellows, J., Gnatt, A., Bjorklund, S., & Kornberg, R. D. (1997). Evidence for a mediator cycle at the initiation ofâtranscription. Proceedings of the National Academy of Sciences, 94(12), 6075â6078.

Authors 6

Jesper Q. Svejstrup (first)
Yang Li (additional)
Jane Fellows (additional)
Averell Gnatt (additional)
Stefan Bjorklund (additional)
Roger D. Kornberg (additional)

References 19 Referenced 100

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:51 p.m.)
Indexed	1 year, 1 month ago (July 4, 2024, 7:12 p.m.)
Issued	28 years, 2 months ago (June 10, 1997)
Published	28 years, 2 months ago (June 10, 1997)
Published Online	28 years, 2 months ago (June 10, 1997)
Published Print	28 years, 2 months ago (June 10, 1997)

Funders 0

None

BibTeX

@article{Svejstrup_1997, title={Evidence for a mediator cycle at the initiation of transcription}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.12.6075}, DOI={10.1073/pnas.94.12.6075}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Svejstrup, Jesper Q. and Li, Yang and Fellows, Jane and Gnatt, Averell and Bjorklund, Stefan and Kornberg, Roger D.}, year={1997}, month=jun, pages={6075–6078} }

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