DOI: 10.1073/pnas.94.1.142. A human protein related to yeast Cdc6p

10.1073/pnas.94.1.142

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The unstable proteins Cdc6p and cdc18 + are essential and rate limiting for the initiation of DNA replication in Saccharomyces cerevisiae and Schizosaccharomyces pombe , respectively, and also participate in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. We have identified Xenopus and human proteins closely related to Cdc6p/cdc18. The human protein, p62 cdc6 , is encoded on chromosome 17q21.3 and includes putative cyclin-dependent kinase phosphorylation sites, destruction boxes, a nucleotide binding/ATPase domain, and a potential leucine zipper. Expression of p62 cdc6 mRNA and protein is suppressed in human diploid fibroblasts made quiescent by serum starvation, and peaks as cells reenter the cell cycle and replicate DNA following serum stimulation. Conservation of structure among proteins involved in initiation suggests that fundamental features of replication complexes are maintained in all eukaryotes.

Bibliography

Williams, R. S., Shohet, R. V., & Stillman, B. (1997). A human protein related to yeastâCdc6p. Proceedings of the National Academy of Sciences, 94(1), 142â147.

Authors 3

R. Sanders Williams (first)
Ralph V. Shohet (additional)
Bruce Stillman (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:31 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:50 p.m.)
Indexed	2 months, 4 weeks ago (May 23, 2025, 4:02 p.m.)
Issued	28 years, 7 months ago (Jan. 7, 1997)
Published	28 years, 7 months ago (Jan. 7, 1997)
Published Online	28 years, 7 months ago (Jan. 7, 1997)
Published Print	28 years, 7 months ago (Jan. 7, 1997)

Funders 0

None

BibTeX

@article{Williams_1997, title={A human protein related to yeast Cdc6p}, volume={94}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.94.1.142}, DOI={10.1073/pnas.94.1.142}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Williams, R. Sanders and Shohet, Ralph V. and Stillman, Bruce}, year={1997}, month=jan, pages={142–147} }

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