DOI: 10.1073/pnas.93.9.3908. Hippocampal atrophy in recurrent major depression.

Hippocampal atrophy in recurrent major depression.

10.1073/pnas.93.9.3908

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. Subjects with a history of major depression had significantly smaller left and right hippocampal volumes with no differences in total cerebral volumes. The degree of hippocampal volume reduction correlated with total duration of major depression. In addition, large (diameter > or = 4.5 mm)-hippocampal low signal foci (LSF) were found within the hippocampus, and their number also correlated with the total number of days depressed. These results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.

Bibliography

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996). Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences, 93(9), 3908â3913.

Authors 5

Y I Sheline (first)
P W Wang (additional)
M H Gado (additional)
J G Csernansky (additional)
M W Vannier (additional)

References 0 Referenced 1,446

None

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:02 p.m.)
Indexed	1 week, 5 days ago (Aug. 19, 2025, 7:02 a.m.)
Issued	29 years, 4 months ago (April 30, 1996)
Published	29 years, 4 months ago (April 30, 1996)
Published Online	29 years, 4 months ago (April 30, 1996)
Published Print	29 years, 4 months ago (April 30, 1996)

Funders 0

None

BibTeX

@article{Sheline_1996, title={Hippocampal atrophy in recurrent major depression.}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.9.3908}, DOI={10.1073/pnas.93.9.3908}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sheline, Y I and Wang, P W and Gado, M H and Csernansky, J G and Vannier, M W}, year={1996}, month=apr, pages={3908–3913} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        19
      ]
    ],
    "date-time": "2025-08-19T11:02:55Z",
    "timestamp": 1755601375316
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "9",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1996,
        4,
        30
      ]
    ]
  },
  "abstract": "<jats:p>Hippocampal volumes of subjects with a history of major depressive episodes but currently in remission and with no known medical comorbidity were compared to matched normal controls by using volumetric magnetic resonance images. Subjects with a history of major depression had significantly smaller left and right hippocampal volumes with no differences in total cerebral volumes. The degree of hippocampal volume reduction correlated with total duration of major depression. In addition, large (diameter &gt; or = 4.5 mm)-hippocampal low signal foci (LSF) were found within the hippocampus, and their number also correlated with the total number of days depressed. These results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.</jats:p>",
  "DOI": "10.1073/pnas.93.9.3908",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        26
      ]
    ],
    "date-time": "2002-07-26T14:35:07Z",
    "timestamp": 1027694107000
  },
  "page": "3908-3913",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 1446,
  "title": "Hippocampal atrophy in recurrent major depression.",
  "prefix": "10.1073",
  "volume": "93",
  "author": [
    {
      "given": "Y I",
      "family": "Sheline",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA."
        }
      ]
    },
    {
      "given": "P W",
      "family": "Wang",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA."
        }
      ]
    },
    {
      "given": "M H",
      "family": "Gado",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA."
        }
      ]
    },
    {
      "given": "J G",
      "family": "Csernansky",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA."
        }
      ]
    },
    {
      "given": "M W",
      "family": "Vannier",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA."
        }
      ]
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1996,
        4,
        30
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.93.9.3908",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T19:02:43Z",
    "timestamp": 1649876563000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.93.9.3908"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1996,
        4,
        30
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "9",
    "published-print": {
      "date-parts": [
        [
          1996,
          4,
          30
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.93.9.3908"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.93.9.3908",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1996,
        4,
        30
      ]
    ]
  },
  "assertion": [
    {
      "value": "1996-04-30",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}