DOI: 10.1073/pnas.93.26.15195. On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins

On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins

10.1073/pnas.93.26.15195

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

During the last 2 years, our laboratory has worked on the elucidation of the molecular basis of capacitative calcium entry (CCE) into cells. Specifically, we tested the hypothesis that CCE channels are formed of subunits encoded in genes related to the Drosophila trp gene. The first step in this pursuit was to search for mammalian trp genes. We found not one but six mammalian genes and cloned several of their cDNAs, some in their full length. As assayed in mammalian cells, overexpression of some mammalian Trps increases CCE, while expression of partial trp cDNAs in antisense orientation can interfere with endogenous CCE. These findings provided a firm connection between CCE and mammalian Trps. This article reviews the known forms of CCE and highlights unanswered questions in our understanding of intracellular Ca 2+ homeostasis and the physiological roles of CCE.

Bibliography

Birnbaumer, L., Zhu, X., Jiang, M., Boulay, G., Peyton, M., Vannier, B., Brown, D., Platano, D., Sadeghi, H., Stefani, E., & Birnbaumer, M. (1996). On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trpâproteins. Proceedings of the National Academy of Sciences, 93(26), 15195â15202.

Authors 11

Lutz Birnbaumer (first)
Xi Zhu (additional)
Meisheng Jiang (additional)
Guylain Boulay (additional)
Michael Peyton (additional)
Brigitte Vannier (additional)
Darren Brown (additional)
Daniela Platano (additional)
Hamid Sadeghi (additional)
Enrico Stefani (additional)
Mariel Birnbaumer (additional)

References 63 Referenced 303

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:44 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:40 p.m.)
Indexed	2 weeks, 6 days ago (Aug. 7, 2025, 5:02 p.m.)
Issued	28 years, 8 months ago (Dec. 24, 1996)
Published	28 years, 8 months ago (Dec. 24, 1996)
Published Online	28 years, 8 months ago (Dec. 24, 1996)
Published Print	28 years, 8 months ago (Dec. 24, 1996)

Funders 0

None

BibTeX

@article{Birnbaumer_1996, title={On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.26.15195}, DOI={10.1073/pnas.93.26.15195}, number={26}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Birnbaumer, Lutz and Zhu, Xi and Jiang, Meisheng and Boulay, Guylain and Peyton, Michael and Vannier, Brigitte and Brown, Darren and Platano, Daniela and Sadeghi, Hamid and Stefani, Enrico and Birnbaumer, Mariel}, year={1996}, month=dec, pages={15195–15202} }

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