DOI: 10.1073/pnas.93.25.14928. Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor

Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor

10.1073/pnas.93.25.14928

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Stimulation of dopamine D1 receptors has profound effects on addictive behavior, movement control, and working memory. Many of these functions depend on dopaminergic systems in the striatum and D1–D2 dopamine receptor synergies have been implicated as well. We show here that deletion of the D1 dopamine receptor produces a neural phenotype in which amphetamine and cocaine, two addictive psychomotor stimulants, can no longer stimulate neurons in the striatum to express cFos or JunB or to regulate dynorphin. By contrast, haloperidol, a typical neuroleptic that acts preferentially at D2-class receptors, remains effective in inducing catalepsy and striatal Fos/Jun expression in the D1 mutants, and these behavioral and neural effects can be blocked by D2 dopamine receptor agonists. These findings demonstrate that D2 dopamine receptors can function without the enabling role of D1 receptors but that D1 dopamine receptors are essential for the control of gene expression and motor behavior by psychomotor stimulants.

Bibliography

Moratalla, R., Xu, M., Tonegawa, S., & Graybiel, A. M. (1996). Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1âdopamineâreceptor. Proceedings of the National Academy of Sciences, 93(25), 14928â14933.

Authors 4

Rosario Moratalla (first)
Ming Xu (additional)
Susumu Tonegawa (additional)
Ann M. Graybiel (additional)

References 45 Referenced 156

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:43 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:30 p.m.)
Indexed	11 months, 3 weeks ago (Sept. 8, 2024, 3:36 p.m.)
Issued	28 years, 8 months ago (Dec. 10, 1996)
Published	28 years, 8 months ago (Dec. 10, 1996)
Published Online	28 years, 8 months ago (Dec. 10, 1996)
Published Print	28 years, 8 months ago (Dec. 10, 1996)

Funders 0

None

BibTeX

@article{Moratalla_1996, title={Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.25.14928}, DOI={10.1073/pnas.93.25.14928}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Moratalla, Rosario and Xu, Ming and Tonegawa, Susumu and Graybiel, Ann M.}, year={1996}, month=dec, pages={14928–14933} }

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