DOI: 10.1073/pnas.93.23.13351. Ca <sup>2+</sup> -induced rebound potentiation of γ-aminobutyric acid-mediated currents requires activation of Ca <sup>2+</sup> /calmodulin-dependent kinase II

Ca 2+ -induced rebound potentiation of γ-aminobutyric acid-mediated currents requires activation of Ca 2+ /calmodulin-dependent kinase II

10.1073/pnas.93.23.13351

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In cerebellar Purkinje neurons, γ-aminobutyric acid (GABA)-mediated inhibitory synaptic transmission undergoes a long-lasting “rebound potentiation” after the activation of excitatory climbing fiber inputs. Rebound potentiation is triggered by the climbing-fiber-induced transient elevation of intracellular Ca 2+ concentration and is expressed as a long-lasting increase of postsynaptic GABA A receptor sensitivity. Herein we show that inhibitors of the Ca 2+ /calmodulin-dependent protein kinase II (CaM-KII) signal transduction pathway effectively block the induction of rebound potentiation. These inhibitors have no effect on the once established rebound potentiation, on voltage-gated Ca 2+ channel currents, or on the basal inhibitory transmission itself. Futhermore, a protein phosphatase inhibitor and the intracellularly applied CaM-KII markedly enhanced GABA-mediated currents in Purkinje neurons. Our results demonstrate that CaM-KII activation and the following phosphorylation are key steps for rebound potentiation.

Bibliography

Kano, M., Kano, M., Fukunaga, K., & Konnerth, A. (1996). Ca 2+ -induced rebound potentiation of Î³-aminobutyric acid-mediated currents requires activation of Ca 2+ /calmodulin-dependentâkinaseâII. Proceedings of the National Academy of Sciences, 93(23), 13351â13356.

Authors 4

Masanobu Kano (first)
Misao Kano (additional)
Kohji Fukunaga (additional)
Arthur Konnerth (additional)

References 53 Referenced 102

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:19 p.m.)
Indexed	1 year ago (Aug. 21, 2024, 8:50 p.m.)
Issued	28 years, 9 months ago (Nov. 12, 1996)
Published	28 years, 9 months ago (Nov. 12, 1996)
Published Online	28 years, 9 months ago (Nov. 12, 1996)
Published Print	28 years, 9 months ago (Nov. 12, 1996)

Funders 0

None

BibTeX

@article{Kano_1996, title={Ca 2+ -induced rebound potentiation of γ-aminobutyric acid-mediated currents requires activation of Ca 2+ /calmodulin-dependent kinase II}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.23.13351}, DOI={10.1073/pnas.93.23.13351}, number={23}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kano, Masanobu and Kano, Misao and Fukunaga, Kohji and Konnerth, Arthur}, year={1996}, month=nov, pages={13351–13356} }

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