DOI: 10.1073/pnas.93.22.12456. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

10.1073/pnas.93.22.12456

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Numerous immature thymocytes undergo apoptosis and are rapidly engulfed by phagocytic thymic macrophages. The macrophage surface receptors involved in apoptotic thymocyte recognition are unknown. We have examined the role of the class A macrophage scavenger receptor (SR-A) in the engulfment of apoptotic thymocytes. Uptake of steroid-treated apoptotic thymocytes by thymic and inflammatory-elicited SR-A positive macrophages is partially inhibited by an anti-SR-A mAb and more completely by a range of scavenger receptor ligands. Thymic macrophages from mice with targeted disruption of the SR-A gene show a 50% reduction in phagocytosis of apoptotic thymocytes in vitro. These data suggest that SR-A may play a role in the clearance of dying cells in the thymus.

Bibliography

Platt, N., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1996). Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proceedings of the National Academy of Sciences, 93(22), 12456â12460.

Authors 5

N Platt (first)
H Suzuki (additional)
Y Kurihara (additional)
T Kodama (additional)
S Gordon (additional)

References 0 Referenced 309

None

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:43 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:02 p.m.)
Indexed	1 week, 1 day ago (Aug. 29, 2025, 6:45 a.m.)
Issued	28 years, 10 months ago (Oct. 29, 1996)
Published	28 years, 10 months ago (Oct. 29, 1996)
Published Online	28 years, 10 months ago (Oct. 29, 1996)
Published Print	28 years, 10 months ago (Oct. 29, 1996)

Funders 0

None

BibTeX

@article{Platt_1996, title={Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.22.12456}, DOI={10.1073/pnas.93.22.12456}, number={22}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Platt, N and Suzuki, H and Kurihara, Y and Kodama, T and Gordon, S}, year={1996}, month=oct, pages={12456–12460} }

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