DOI: 10.1073/pnas.93.20.10626. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

10.1073/pnas.93.20.10626

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1.

Bibliography

Yao, T. P., Ku, G., Zhou, N., Scully, R., & Livingston, D. M. (1996). The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proceedings of the National Academy of Sciences, 93(20), 10626â10631.

Authors 5

T P Yao (first)
G Ku (additional)
N Zhou (additional)
R Scully (additional)
D M Livingston (additional)

References 0 Referenced 344

None

Dates

Type	When
Created	23 years ago (July 26, 2002, 6:34 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:21 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 6, 2025, 8:32 a.m.)
Issued	28 years, 10 months ago (Oct. 1, 1996)
Published	28 years, 10 months ago (Oct. 1, 1996)
Published Online	28 years, 10 months ago (Oct. 1, 1996)
Published Print	28 years, 10 months ago (Oct. 1, 1996)

Funders 0

None

BibTeX

@article{Yao_1996, title={The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.20.10626}, DOI={10.1073/pnas.93.20.10626}, number={20}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Yao, T P and Ku, G and Zhou, N and Scully, R and Livingston, D M}, year={1996}, month=oct, pages={10626–10631} }

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