DOI: 10.1073/pnas.93.17.9235. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

10.1073/pnas.93.17.9235

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic transmission is associated with this illness, but direct observation of abnormalities of dopamine function in schizophrenia has remained elusive. We used a newly developed single photon emission computerized tomography method to measure amphetamine-induced dopamine release in the striatum of fifteen patients with schizophrenia and fifteen healthy controls. Amphetamine-induced dopamine release was estimated by the amphetamine-induced reduction in dopamine D2 receptor availability, measured as the binding potential of the specific D2 receptor radiotracer [123I] (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl) methyl]benzamide ([123I]IBZM). The amphetamine-induced decrease in [123I]IBZM binding potential was significantly greater in the schizophrenic group (-19.5 +/- 4.1%) compared with the control group (-7.6 +/- 2.1%). In the schizophrenic group, elevated amphetamine effect on [123I]IBZM binding potential was associated with emergence or worsening of positive psychotic symptoms. This result suggests that psychotic symptoms elicited in this experimental setting in schizophrenic patients are associated with exaggerated stimulation of dopaminergic transmission. Such an observation would be compatible with an abnormal responsiveness of dopaminergic neurons in schizophrenia.

Bibliography

Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., DâSouza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., Baldwin, R. M., Seibyl, J. P., Krystal, J. H., Charney, D. S., & Innis, R. B. (1996). Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings of the National Academy of Sciences, 93(17), 9235â9240.

Authors 15

M Laruelle (first)
A Abi-Dargham (additional)
C H van Dyck (additional)
R Gil (additional)
C D D'Souza (additional)
J Erdos (additional)
E McCance (additional)
W Rosenblatt (additional)
C Fingado (additional)
S S Zoghbi (additional)
R M Baldwin (additional)
J P Seibyl (additional)
J H Krystal (additional)
D S Charney (additional)
R B Innis (additional)

References 0 Referenced 988

None

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:34 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:15 p.m.)
Indexed	2 days, 13 hours ago (Aug. 30, 2025, 1:03 p.m.)
Issued	29 years ago (Aug. 20, 1996)
Published	29 years ago (Aug. 20, 1996)
Published Online	29 years ago (Aug. 20, 1996)
Published Print	29 years ago (Aug. 20, 1996)

Funders 0

None

BibTeX

@article{Laruelle_1996, title={Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.17.9235}, DOI={10.1073/pnas.93.17.9235}, number={17}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Laruelle, M and Abi-Dargham, A and van Dyck, C H and Gil, R and D’Souza, C D and Erdos, J and McCance, E and Rosenblatt, W and Fingado, C and Zoghbi, S S and Baldwin, R M and Seibyl, J P and Krystal, J H and Charney, D S and Innis, R B}, year={1996}, month=aug, pages={9235–9240} }

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