DOI: 10.1073/pnas.93.1.166. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.

Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.

10.1073/pnas.93.1.166

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The trinucleotide/amino acid relationships of the present-day genetic code are established by the amino-acylation reactions of tRNA synthetases, whereby each of 20 specific amino acids is attached to its cognate tRNAs, which bear anticodon trinucleotides. Because of its universality, the appearance of the modern genetic code is thought to predate the separation of prokaryotic and eukaryotic organisms in the universal phylogenetic tree. In the light of new sequence information, we present here a phylogenetic analysis that shows an unusual picture for tyrosyl- and tryptophanyl-tRNA synthetases. Ij particular, the eukaryotic tyrosyl- and tryptophanyl-tRNA synthetases are more related to each other than to their respective prokaryotic counterparts. In contrast, each of the other 18 eukaryotic synthetases is more related to its prokaryotic counterpart than to any eukaryotic synthetase specific for a different amino acid. Our results raise the possibility that present day tyrosyl- and tryptophanyl-tRNA synthetases appeared after the separation of nucleated cells from eubacteria. The results have implications for the development of the genetic code.

Bibliography

Ribas de Pouplana, L., Frugier, M., Quinn, C. L., & Schimmel, P. (1996). Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria. Proceedings of the National Academy of Sciences, 93(1), 166â170.

Authors 4

L Ribas de Pouplana (first)
M Frugier (additional)
C L Quinn (additional)
P Schimmel (additional)

References 0 Referenced 41

None

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:34 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:12 p.m.)
Indexed	1 year, 6 months ago (Feb. 26, 2024, 1:45 a.m.)
Issued	29 years, 7 months ago (Jan. 9, 1996)
Published	29 years, 7 months ago (Jan. 9, 1996)
Published Online	29 years, 7 months ago (Jan. 9, 1996)
Published Print	29 years, 7 months ago (Jan. 9, 1996)

Funders 0

None

BibTeX

@article{Ribas_de_Pouplana_1996, title={Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria.}, volume={93}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.93.1.166}, DOI={10.1073/pnas.93.1.166}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ribas de Pouplana, L and Frugier, M and Quinn, C L and Schimmel, P}, year={1996}, month=jan, pages={166–170} }

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