DOI: 10.1073/pnas.92.8.3626. Toward an outline of the topography of a realistic protein-folding funnel.

Toward an outline of the topography of a realistic protein-folding funnel.

10.1073/pnas.92.8.3626

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Experimental information on the structure and dynamics of molten globules gives estimates for the energy landscape's characteristics for folding highly helical proteins, when supplemented by a theory of the helix-coil transition in collapsed heteropolymers. A law of corresponding states relating simulations on small lattice models to real proteins possessing many more degrees of freedom results. This correspondence reveals parallels between "minimalist" lattice results and recent experimental results for the degree of native character of the folding transition state and molten globule and also pinpoints the needs of further experiments.

Bibliography

Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D. (1995). Toward an outline of the topography of a realistic protein-folding funnel. Proceedings of the National Academy of Sciences, 92(8), 3626â3630.

Authors 4

J N Onuchic (first)
P G Wolynes (additional)
Z Luthey-Schulten (additional)
N D Socci (additional)

References 0 Referenced 466

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:31 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:05 p.m.)
Indexed	6 days, 15 hours ago (Aug. 23, 2025, 9:15 p.m.)
Issued	30 years, 4 months ago (April 11, 1995)
Published	30 years, 4 months ago (April 11, 1995)
Published Online	30 years, 4 months ago (April 11, 1995)
Published Print	30 years, 4 months ago (April 11, 1995)

Funders 0

None

BibTeX

@article{Onuchic_1995, title={Toward an outline of the topography of a realistic protein-folding funnel.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.8.3626}, DOI={10.1073/pnas.92.8.3626}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Onuchic, J N and Wolynes, P G and Luthey-Schulten, Z and Socci, N D}, year={1995}, month=apr, pages={3626–3630} }

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