DOI: 10.1073/pnas.92.25.11711. Primary structure and functional expression of a cGMP-gated potassium channel.

Primary structure and functional expression of a cGMP-gated potassium channel.

10.1073/pnas.92.25.11711

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cyclic nucleotides modulate potassium (K) channel activity in many cells and are thought to act indirectly by inducing channel protein phosphorylation. Herein we report the isolation from rabbit of a gene encoding a K channel (Kcn1) that is specifically activated by cGMP and not by cAMP. Analysis of the deduced amino acid sequence (725 amino acids) indicates that, in addition to a core region that is highly homologous to Shaker K channels, Kcn1 also contains a cysteine-rich region similar to that of ligand-gated ion channels and a cyclic nucleotide-binding region. Northern blot analysis detects gene expression in kidney, aorta, and brain. Kcn1 represents a class of K channels that may be specifically regulated by cGMP and could play an important role in mediating the effects of substances, such as nitric oxide, that increase intracellular cGMP.

Bibliography

Yao, X., Segal, A. S., Welling, P., Zhang, X., McNicholas, C. M., Engel, D., Boulpaep, E. L., & Desir, G. V. (1995). Primary structure and functional expression of a cGMP-gated potassium channel. Proceedings of the National Academy of Sciences, 92(25), 11711â11715.

Authors 8

X Yao (first)
A S Segal (additional)
P Welling (additional)
X Zhang (additional)
C M McNicholas (additional)
D Engel (additional)
E L Boulpaep (additional)
G V Desir (additional)

References 0 Referenced 104

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:24 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:57 p.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 2:02 a.m.)
Issued	29 years, 8 months ago (Dec. 5, 1995)
Published	29 years, 8 months ago (Dec. 5, 1995)
Published Online	29 years, 8 months ago (Dec. 5, 1995)
Published Print	29 years, 8 months ago (Dec. 5, 1995)

Funders 0

None

BibTeX

@article{Yao_1995, title={Primary structure and functional expression of a cGMP-gated potassium channel.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.25.11711}, DOI={10.1073/pnas.92.25.11711}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Yao, X and Segal, A S and Welling, P and Zhang, X and McNicholas, C M and Engel, D and Boulpaep, E L and Desir, G V}, year={1995}, month=dec, pages={11711–11715} }

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