DOI: 10.1073/pnas.92.24.11264. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

10.1073/pnas.92.24.11264

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cyclin A is involved in the control of S phase and mitosis in mammalian cells. Expression of the cyclin A gene in nontransformed cells is characterized by repression of its promoter during the G1 phase of the cell cycle and its induction at S-phase entry. We show that this mode of regulation is mediated by the transcription factor E2F, which binds to a specific site in the cyclin A promoter. It differs from the prototype E2F site in nucleotide sequence and protein binding; it is bound by E2F complexes containing cyclin E and p107 but not pRB. Ectopic expression of cyclin D1 triggers premature activation of the cyclin A promoter by E2F, and this effect is blocked by the tumor suppressor protein p16INK4.

Bibliography

Schulze, A., Zerfass, K., Spitkovsky, D., Middendorp, S., BergÃ¨s, J., Helin, K., Jansen-DÃ¼rr, P., & Henglein, B. (1995). Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proceedings of the National Academy of Sciences, 92(24), 11264â11268.

Authors 8

A Schulze (first)
K Zerfass (additional)
D Spitkovsky (additional)
S Middendorp (additional)
J Bergès (additional)
K Helin (additional)
P Jansen-Dürr (additional)
B Henglein (additional)

References 0 Referenced 276

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 9:24 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:52 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 5, 2025, 9:12 a.m.)
Issued	29 years, 9 months ago (Nov. 21, 1995)
Published	29 years, 9 months ago (Nov. 21, 1995)
Published Online	29 years, 9 months ago (Nov. 21, 1995)
Published Print	29 years, 9 months ago (Nov. 21, 1995)

Funders 0

None

BibTeX

@article{Schulze_1995, title={Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.24.11264}, DOI={10.1073/pnas.92.24.11264}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Schulze, A and Zerfass, K and Spitkovsky, D and Middendorp, S and Bergès, J and Helin, K and Jansen-Dürr, P and Henglein, B}, year={1995}, month=nov, pages={11264–11268} }

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