DOI: 10.1073/pnas.92.24.10864. Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

10.1073/pnas.92.24.10864

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Sin4 and Rgr1 proteins, previously shown by genetic studies to play both positive and negative roles in the transcriptional regulation of many genes, are identified here as components of mediator and RNA polymerase II holoenzyme complexes. Results with Sin4 deletion and Rgr1 truncation strains indicate the association of these proteins in a subcomplex comprising Sin4, Rgr1, Gal11, and a 50-kDa polypeptide. Taken together with the previous genetic evidence, our findings point to a role of the mediator in repression as well as in transcriptional activation.

Bibliography

Li, Y., Bjorklund, S., Jiang, Y. W., Kim, Y. J., Lane, W. S., Stillman, D. J., & Kornberg, R. D. (1995). Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme. Proceedings of the National Academy of Sciences, 92(24), 10864â10868.

Authors 7

Y Li (first)
S Bjorklund (additional)
Y W Jiang (additional)
Y J Kim (additional)
W S Lane (additional)
D J Stillman (additional)
R D Kornberg (additional)

References 0 Referenced 195

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 9:24 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:51 p.m.)
Indexed	2 months ago (June 27, 2025, 6:52 a.m.)
Issued	29 years, 9 months ago (Nov. 21, 1995)
Published	29 years, 9 months ago (Nov. 21, 1995)
Published Online	29 years, 9 months ago (Nov. 21, 1995)
Published Print	29 years, 9 months ago (Nov. 21, 1995)

Funders 0

None

BibTeX

@article{Li_1995, title={Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.24.10864}, DOI={10.1073/pnas.92.24.10864}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Li, Y and Bjorklund, S and Jiang, Y W and Kim, Y J and Lane, W S and Stillman, D J and Kornberg, R D}, year={1995}, month=nov, pages={10864–10868} }

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