DOI: 10.1073/pnas.92.23.10648. Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy.

Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy.

10.1073/pnas.92.23.10648

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The structures of Sindbis virus and Ross River virus complexed with Fab fragments from monoclonal antibodies have been determined from cryoelectron micrographs. Both antibodies chosen for this study bind to regions of the virions that have been implicated in cell-receptor recognition and recognize epitopes on the E2 glycoprotein. The two structures show that the Fab fragments bind to the outermost tip of the trimeric envelope spike protein. Hence, the same region of both the Sindbis virus and Ross River virus envelope spike is composed of E2 and is involved in recognition of the cellular receptor.

Bibliography

Smith, T. J., Cheng, R. H., Olson, N. H., Peterson, P., Chase, E., Kuhn, R. J., & Baker, T. S. (1995). Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy. Proceedings of the National Academy of Sciences, 92(23), 10648â10652.

Authors 7

T J Smith (first)
R H Cheng (additional)
N H Olson (additional)
P Peterson (additional)
E Chase (additional)
R J Kuhn (additional)
T S Baker (additional)

References 0 Referenced 124

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:23 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:06 p.m.)
Indexed	1 month, 2 weeks ago (July 8, 2025, 10:31 a.m.)
Issued	29 years, 9 months ago (Nov. 7, 1995)
Published	29 years, 9 months ago (Nov. 7, 1995)
Published Online	29 years, 9 months ago (Nov. 7, 1995)
Published Print	29 years, 9 months ago (Nov. 7, 1995)

Funders 0

None

BibTeX

@article{Smith_1995, title={Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.23.10648}, DOI={10.1073/pnas.92.23.10648}, number={23}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Smith, T J and Cheng, R H and Olson, N H and Peterson, P and Chase, E and Kuhn, R J and Baker, T S}, year={1995}, month=nov, pages={10648–10652} }

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