DOI: 10.1073/pnas.92.21.9801. Simple model of protein folding kinetics.

Simple model of protein folding kinetics.

10.1073/pnas.92.21.9801

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A simple model of the kinetics of protein folding is presented. The reaction coordinate is the "correctness" of a configuration compared with the native state. The model has a gap in the energy spectrum, a large configurational entropy, a free energy barrier between folded and partially folded states, and a good thermodynamic folding transition. Folding kinetics is described by a master equation. The folding time is estimated by means of a local thermodynamic equilibrium assumption and then is calculated both numerically and analytically by solving the master equation. The folding time has a maximum near the folding transition temperature and can have a minimum at a lower temperature.

Bibliography

Zwanzig, R. (1995). Simple model of protein folding kinetics. Proceedings of the National Academy of Sciences, 92(21), 9801â9804.

Authors 1

R Zwanzig (first)

References 0 Referenced 182

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:04 p.m.)
Indexed	1 month ago (July 25, 2025, 6:21 a.m.)
Issued	29 years, 10 months ago (Oct. 10, 1995)
Published	29 years, 10 months ago (Oct. 10, 1995)
Published Online	29 years, 10 months ago (Oct. 10, 1995)
Published Print	29 years, 10 months ago (Oct. 10, 1995)

Funders 0

None

BibTeX

@article{Zwanzig_1995, title={Simple model of protein folding kinetics.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.21.9801}, DOI={10.1073/pnas.92.21.9801}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zwanzig, R}, year={1995}, month=oct, pages={9801–9804} }

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