DOI: 10.1073/pnas.92.21.9697. Spatial learning with a minislab in the dorsal hippocampus.

Spatial learning with a minislab in the dorsal hippocampus.

10.1073/pnas.92.21.9697

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have determined the volume and location of hippocampal tissue required for normal acquisition of a spatial memory task. Ibotenic acid was used to make bilateral symmetric lesions of 20-100% of hippocampal volume. Even a small transverse block (minislab) of the hippocampus (down to 26% of the total) could support spatial learning in a water maze, provided it was at the septal (dorsal) pole of the hippocampus. Lesions of the septal pole, leaving 60% of the hippocampi intact, caused a learning deficit, although normal electrophysiological responses, synaptic plasticity, and preserved acetylcholinesterase staining argue for adequate function of the remaining tissue. Thus, with an otherwise normal brain, hippocampal-dependent spatial learning only requires a minislab of dorsal hippocampal tissue.

Bibliography

Moser, M. B., Moser, E. I., Forrest, E., Andersen, P., & Morris, R. G. (1995). Spatial learning with a minislab in the dorsal hippocampus. Proceedings of the National Academy of Sciences, 92(21), 9697â9701.

Authors 5

M B Moser (first)
E I Moser (additional)
E Forrest (additional)
P Andersen (additional)
R G Morris (additional)

References 0 Referenced 694

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 9:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:03 p.m.)
Indexed	5 days, 18 hours ago (Aug. 30, 2025, 12:27 p.m.)
Issued	29 years, 10 months ago (Oct. 10, 1995)
Published	29 years, 10 months ago (Oct. 10, 1995)
Published Online	29 years, 10 months ago (Oct. 10, 1995)
Published Print	29 years, 10 months ago (Oct. 10, 1995)

Funders 0

None

BibTeX

@article{Moser_1995, title={Spatial learning with a minislab in the dorsal hippocampus.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.21.9697}, DOI={10.1073/pnas.92.21.9697}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Moser, M B and Moser, E I and Forrest, E and Andersen, P and Morris, R G}, year={1995}, month=oct, pages={9697–9701} }

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