DOI: 10.1073/pnas.92.21.9525. A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.

A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.

10.1073/pnas.92.21.9525

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Nuclear hormone receptors are transcription factors that require multiple protein-protein interactions to regulate the expression of their target genes. Using the yeast two-hybrid system, we identified a protein, thyroid hormone receptor uncoupling protein (TRUP), that specifically interacts with a region of the human thyroid hormone receptor (TR) consisting of the hinge region and the N-terminal portion of the ligand binding domain in a hormone-independent manner. Interestingly, TRUP inhibits transactivation by TR and the retinoic acid receptor but has no effect on the estrogen receptor or the retinoid X receptor in mammalian cells. We also demonstrate that TRUP exerts its action on TR and retinoic acid receptor by interfering with their abilities to interact with their DNA. TRUP represents a type of regulatory protein that modulates the transcriptional activity of a subclass of the nuclear hormone receptor superfamily by preventing interaction with their genomic response elements.

Authors 4

T P Burris (first)
Z Nawaz (additional)
M J Tsai (additional)
B W O'Malley (additional)

References 0 Referenced 87

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:04 p.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 12:47 a.m.)
Issued	29 years, 10 months ago (Oct. 10, 1995)
Published	29 years, 10 months ago (Oct. 10, 1995)
Published Online	29 years, 10 months ago (Oct. 10, 1995)
Published Print	29 years, 10 months ago (Oct. 10, 1995)

Funders 0

None

BibTeX

@article{Burris_1995, title={A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.21.9525}, DOI={10.1073/pnas.92.21.9525}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Burris, T P and Nawaz, Z and Tsai, M J and O’Malley, B W}, year={1995}, month=oct, pages={9525–9529} }

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