DOI: 10.1073/pnas.92.18.8522. Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.

10.1073/pnas.92.18.8522

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Rodent tumor cells engineered to secrete cytokines such as interleukin 2 (IL-2) or IL-4 are rejected by syngeneic recipients due to an enhanced antitumor host immune response. An adenovirus vector (AdCAIL-2) containing the human IL-2 gene has been constructed and shown to direct secretion of high levels of human IL-2 in infected tumor cells. AdCAIL-2 induces regression of tumors in a transgenic mouse model of mammary adenocarcinoma following intratumoral injection. Elimination of existing tumors in this way results in immunity against a second challenge with tumor cells. These findings suggest that adenovirus vectors expressing cytokines may form the basis for highly effective immunotherapies of human cancers.

Bibliography

Addison, C. L., Braciak, T., Ralston, R., Muller, W. J., Gauldie, J., & Graham, F. L. (1995). Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model. Proceedings of the National Academy of Sciences, 92(18), 8522â8526.

Authors 6

C L Addison (first)
T Braciak (additional)
R Ralston (additional)
W J Muller (additional)
J Gauldie (additional)
F L Graham (additional)

References 0 Referenced 130

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:17 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:49 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 2, 2025, 12:12 a.m.)
Issued	29 years, 11 months ago (Aug. 29, 1995)
Published	29 years, 11 months ago (Aug. 29, 1995)
Published Online	29 years, 11 months ago (Aug. 29, 1995)
Published Print	29 years, 11 months ago (Aug. 29, 1995)

Funders 0

None

BibTeX

@article{Addison_1995, title={Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.18.8522}, DOI={10.1073/pnas.92.18.8522}, number={18}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Addison, C L and Braciak, T and Ralston, R and Muller, W J and Gauldie, J and Graham, F L}, year={1995}, month=aug, pages={8522–8526} }

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