DOI: 10.1073/pnas.92.17.8011. An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.

10.1073/pnas.92.17.8011

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad repeats found in coiled coils. When the yeast p24 isoform, yp24A, is knocked out in a strain defective for vesicle fusion, a dramatic reduction in the accumulation of transport vesicles is observed. Together, these results indicate a role for this protein family in the budding of coatamer-coated and other species of coated vesicles.

Bibliography

Stamnes, M. A., Craighead, M. W., Hoe, M. H., Lampen, N., Geromanos, S., Tempst, P., & Rothman, J. E. (1995). An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proceedings of the National Academy of Sciences, 92(17), 8011â8015.

Authors 7

M A Stamnes (first)
M W Craighead (additional)
M H Hoe (additional)
N Lampen (additional)
S Geromanos (additional)
P Tempst (additional)
J E Rothman (additional)

References 0 Referenced 184

None

Dates

Type	When
Created	19 years, 2 months ago (June 1, 2006, 8:50 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:53 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 5, 2025, 8:50 a.m.)
Issued	30 years ago (Aug. 15, 1995)
Published	30 years ago (Aug. 15, 1995)
Published Online	30 years ago (Aug. 15, 1995)
Published Print	30 years ago (Aug. 15, 1995)

Funders 0

None

BibTeX

@article{Stamnes_1995, title={An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.17.8011}, DOI={10.1073/pnas.92.17.8011}, number={17}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Stamnes, M A and Craighead, M W and Hoe, M H and Lampen, N and Geromanos, S and Tempst, P and Rothman, J E}, year={1995}, month=aug, pages={8011–8015} }

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