DOI: 10.1073/pnas.92.10.4562. Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

10.1073/pnas.92.10.4562

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Down-regulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (> 10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

Bibliography

Singh, R. K., Gutman, M., Bucana, C. D., Sanchez, R., Llansa, N., & Fidler, I. J. (1995). Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proceedings of the National Academy of Sciences, 92(10), 4562â4566.

Authors 6

R K Singh (first)
M Gutman (additional)
C D Bucana (additional)
R Sanchez (additional)
N Llansa (additional)
I J Fidler (additional)

References 0 Referenced 336

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:57 p.m.)
Indexed	3 weeks, 5 days ago (July 30, 2025, 9:58 a.m.)
Issued	30 years, 3 months ago (May 9, 1995)
Published	30 years, 3 months ago (May 9, 1995)
Published Online	30 years, 3 months ago (May 9, 1995)
Published Print	30 years, 3 months ago (May 9, 1995)

Funders 0

None

BibTeX

@article{Singh_1995, title={Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.10.4562}, DOI={10.1073/pnas.92.10.4562}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Singh, R K and Gutman, M and Bucana, C D and Sanchez, R and Llansa, N and Fidler, I J}, year={1995}, month=may, pages={4562–4566} }

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