DOI: 10.1073/pnas.92.10.4512. Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.

Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.

10.1073/pnas.92.10.4512

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Expression of the 70-kDa polypeptide of human Ku autoantigen in rat cells is shown to suppress specifically the induction of hsp70 upon heat shock. Thermal induction of other heat shock proteins is not significantly affected, nor is the state of phosphorylation or the DNA-binding ability of the heat shock transcription factor HSF1. These findings support a model in which hsp70 gene expression is controlled by a second regulatory factor in addition to the positive activator HSF1. The Ku autoantigen, or a protein closely related to it, is likely to be involved in the regulation of hsp70 expression.

Bibliography

Li, G. C., Yang, S. H., Kim, D., Nussenzweig, A., Ouyang, H., Wei, J., Burgman, P., & Li, L. (1995). Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proceedings of the National Academy of Sciences, 92(10), 4512â4516.

Authors 8

G C Li (first)
S H Yang (additional)
D Kim (additional)
A Nussenzweig (additional)
H Ouyang (additional)
J Wei (additional)
P Burgman (additional)
L Li (additional)

References 0 Referenced 41

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:55 p.m.)
Indexed	1 year, 2 months ago (June 7, 2024, 4:38 a.m.)
Issued	30 years, 3 months ago (May 9, 1995)
Published	30 years, 3 months ago (May 9, 1995)
Published Online	30 years, 3 months ago (May 9, 1995)
Published Print	30 years, 3 months ago (May 9, 1995)

Funders 0

None

BibTeX

@article{Li_1995, title={Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.}, volume={92}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.92.10.4512}, DOI={10.1073/pnas.92.10.4512}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Li, G C and Yang, S H and Kim, D and Nussenzweig, A and Ouyang, H and Wei, J and Burgman, P and Li, L}, year={1995}, month=may, pages={4512–4516} }

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