DOI: 10.1073/pnas.91.9.3931. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.

Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.

10.1073/pnas.91.9.3931

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cyclophilin B is targeted to the secretory pathway via an endoplasmic reticulum signal sequence. We analyzed the localization and trafficking of endogenous and transfected cyclophilin B in mammalian cells. Cyclophilin B accumulates both in the endoplasmic reticulum and in complexes on the plasma membrane. The immunosuppressant cyclosporin A specifically mobilizes cyclophilin B from the endoplasmic reticulum, and promotes the secretion of cyclophilin B into the medium. We suggest that cyclosporin A competes with endogenous plasma membrane proteins for association with cyclophilin B in the secretory pathway. These findings argue in favor of a role for cyclophilin B as a chaperone to proteins destined for the plasma membrane, rather than solely as a proline isomerase functioning within the endoplasmic reticulum.

Bibliography

Price, E. R., Jin, M., Lim, D., Pati, S., Walsh, C. T., & McKeon, F. D. (1994). Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. Proceedings of the National Academy of Sciences, 91(9), 3931â3935.

Authors 6

E R Price (first)
M Jin (additional)
D Lim (additional)
S Pati (additional)
C T Walsh (additional)
F D McKeon (additional)

References 0 Referenced 95

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 9:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:13 p.m.)
Indexed	1 month, 2 weeks ago (July 16, 2025, 7:58 a.m.)
Issued	31 years, 4 months ago (April 26, 1994)
Published	31 years, 4 months ago (April 26, 1994)
Published Online	31 years, 4 months ago (April 26, 1994)
Published Print	31 years, 4 months ago (April 26, 1994)

Funders 0

None

BibTeX

@article{Price_1994, title={Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.9.3931}, DOI={10.1073/pnas.91.9.3931}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Price, E R and Jin, M and Lim, D and Pati, S and Walsh, C T and McKeon, F D}, year={1994}, month=apr, pages={3931–3935} }

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