DOI: 10.1073/pnas.91.9.3505. Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.

Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.

10.1073/pnas.91.9.3505

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cyclic nucleotide-gated cation channels are essential in visual and olfactory signal transduction. An additional member of the cGMP-gated channel family, termed CNG-3, has been cloned from bovine kidney. Its deduced amino acid sequence is 60% and 62% identical with the CNG-channel proteins from bovine rod outer segment and bovine olfactory epithelium, respectively. Northern analysis and sequences amplified by the PCR showed that the CNG-3 mRNA is present in testis, kidney, and heart. Calcium permeated the expressed channel in the presence of extracellular Mg2+ and Na+ at membrane potentials from -100 to +45 mV. It is likely that CNG-3 protein is responsible for cGMP-induced Ca2+ entry in cells other than sensory cells.

Bibliography

Biel, M., Zong, X., Distler, M., Bosse, E., Klugbauer, N., Murakami, M., Flockerzi, V., & Hofmann, F. (1994). Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart. Proceedings of the National Academy of Sciences, 91(9), 3505â3509.

Authors 8

M Biel (first)
X Zong (additional)
M Distler (additional)
E Bosse (additional)
N Klugbauer (additional)
M Murakami (additional)
V Flockerzi (additional)
F Hofmann (additional)

References 0 Referenced 140

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:09 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:11 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 1:10 a.m.)
Issued	31 years, 4 months ago (April 26, 1994)
Published	31 years, 4 months ago (April 26, 1994)
Published Online	31 years, 4 months ago (April 26, 1994)
Published Print	31 years, 4 months ago (April 26, 1994)

Funders 0

None

BibTeX

@article{Biel_1994, title={Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.9.3505}, DOI={10.1073/pnas.91.9.3505}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Biel, M and Zong, X and Distler, M and Bosse, E and Klugbauer, N and Murakami, M and Flockerzi, V and Hofmann, F}, year={1994}, month=apr, pages={3505–3509} }

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