DOI: 10.1073/pnas.91.4.1356. Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.

Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.

10.1073/pnas.91.4.1356

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The tetramer binds to the human immunodeficiency virus envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.

Bibliography

Wyatt, J. R., Vickers, T. A., Roberson, J. L., Buckheit, R. W., Klimkait, T., DeBaets, E., Davis, P. W., Rayner, B., Imbach, J. L., & Ecker, D. J. (1994). Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion. Proceedings of the National Academy of Sciences, 91(4), 1356â1360.

Authors 10

J R Wyatt (first)
T A Vickers (additional)
J L Roberson (additional)
R W Buckheit (additional)
T Klimkait (additional)
E DeBaets (additional)
P W Davis (additional)
B Rayner (additional)
J L Imbach (additional)
D J Ecker (additional)

References 0 Referenced 235

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:03 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:49 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 2, 2025, 12:48 a.m.)
Issued	31 years, 6 months ago (Feb. 15, 1994)
Published	31 years, 6 months ago (Feb. 15, 1994)
Published Online	31 years, 6 months ago (Feb. 15, 1994)
Published Print	31 years, 6 months ago (Feb. 15, 1994)

Funders 0

None

BibTeX

@article{Wyatt_1994, title={Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.4.1356}, DOI={10.1073/pnas.91.4.1356}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Wyatt, J R and Vickers, T A and Roberson, J L and Buckheit, R W and Klimkait, T and DeBaets, E and Davis, P W and Rayner, B and Imbach, J L and Ecker, D J}, year={1994}, month=feb, pages={1356–1360} }

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