DOI: 10.1073/pnas.91.25.11973. The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast.

The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast.

10.1073/pnas.91.25.11973

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have cloned the gene encoding the protein Mas22p, which spans the outer membrane of yeast mitochondria. Cells that completely lack Mas22p are inviable. The plasmid-borne MAS22 gene suppresses several defects resulting from the deletion of one or more of the mitochondrial protein import receptors. Defects of Mas20p-deficient cells are explained by the reduced level of Mas22p in these mutants. Mas22p has one acidic domain in the cytosol and a second acidic domain in the mitochondrial intermembrane space. We suggest that these domains of Mas22p on either side of the outer membrane function as a relay system for transferring the basic targeting sequences of precursor proteins into the mitochondria.

Bibliography

Lithgow, T., Junne, T., Suda, K., Gratzer, S., & Schatz, G. (1994). The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast. Proceedings of the National Academy of Sciences, 91(25), 11973â11977.

Authors 5

T Lithgow (first)
T Junne (additional)
K Suda (additional)
S Gratzer (additional)
G Schatz (additional)

References 0 Referenced 124

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 9:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 2:11 p.m.)
Indexed	2 weeks, 3 days ago (Aug. 5, 2025, 8:15 a.m.)
Issued	30 years, 8 months ago (Dec. 6, 1994)
Published	30 years, 8 months ago (Dec. 6, 1994)
Published Online	30 years, 8 months ago (Dec. 6, 1994)
Published Print	30 years, 8 months ago (Dec. 6, 1994)

Funders 0

None

BibTeX

@article{Lithgow_1994, title={The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.25.11973}, DOI={10.1073/pnas.91.25.11973}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lithgow, T and Junne, T and Suda, K and Gratzer, S and Schatz, G}, year={1994}, month=dec, pages={11973–11977} }

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