DOI: 10.1073/pnas.91.21.10069. Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers.

Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers.

10.1073/pnas.91.21.10069

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

To investigate the lateral organization of sterols in membranes, the fluorescence intensity of dehydroergosterol at different mole fractions in liquid crystalline dimyristoyl phosphatidylcholine bilayers was examined. A number of intensity drops were observed at specific mole fractions, as predicted from a hexagonal super-lattice model. The fluorescence dips provide compelling evidence that a naturally occurring sterol is regularly distributed at fixed compositional fractions, consistent with the presence of hexagonal super-lattices in the fluid membranes. Regularly distributed regions, however, coexist with irregularly distributed regions. The extent of regular distribution varies periodically with sterol mole fraction and, consequently, similar variations take place in the membrane volume and lipid packing. This level of modulation in local membrane structure by minute changes in sterol concentration should have profound implications for the functional role of cholesterol content in cell membranes.

Bibliography

Chong, P. L. (1994). Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers. Proceedings of the National Academy of Sciences, 91(21), 10069â10073.

Authors 1

P L Chong (first)

References 0 Referenced 118

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:57 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:51 p.m.)
Indexed	2 months, 2 weeks ago (June 13, 2025, 7:45 a.m.)
Issued	30 years, 10 months ago (Oct. 11, 1994)
Published	30 years, 10 months ago (Oct. 11, 1994)
Published Online	30 years, 10 months ago (Oct. 11, 1994)
Published Print	30 years, 10 months ago (Oct. 11, 1994)

Funders 0

None

BibTeX

@article{Chong_1994, title={Evidence for regular distribution of sterols in liquid crystalline phosphatidylcholine bilayers.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.21.10069}, DOI={10.1073/pnas.91.21.10069}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chong, P L}, year={1994}, month=oct, pages={10069–10073} }

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