DOI: 10.1073/pnas.91.2.709. Function of a human cyclin gene as an oncogene.

Function of a human cyclin gene as an oncogene.

10.1073/pnas.91.2.709

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.

Bibliography

Hinds, P. W., Dowdy, S. F., Eaton, E. N., Arnold, A., & Weinberg, R. A. (1994). Function of a human cyclin gene as an oncogene. Proceedings of the National Academy of Sciences, 91(2), 709â713.

Authors 5

P W Hinds (first)
S F Dowdy (additional)
E N Eaton (additional)
A Arnold (additional)
R A Weinberg (additional)

References 0 Referenced 329

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:56 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:59 p.m.)
Indexed	3 weeks, 5 days ago (July 30, 2025, 11:11 a.m.)
Issued	31 years, 7 months ago (Jan. 18, 1994)
Published	31 years, 7 months ago (Jan. 18, 1994)
Published Online	31 years, 7 months ago (Jan. 18, 1994)
Published Print	31 years, 7 months ago (Jan. 18, 1994)

Funders 0

None

BibTeX

@article{Hinds_1994, title={Function of a human cyclin gene as an oncogene.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.2.709}, DOI={10.1073/pnas.91.2.709}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hinds, P W and Dowdy, S F and Eaton, E N and Arnold, A and Weinberg, R A}, year={1994}, month=jan, pages={709–713} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T15:11:00Z",
    "timestamp": 1753888260073
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "2",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        1,
        18
      ]
    ]
  },
  "abstract": "<jats:p>The cyclin D1 (PRAD1, CCND1) gene is affected by translocations and amplification in the genomes of a number of human tumors, suggesting that these changes confer growth advantage on developing tumor cell clones. We show here that in cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene. In such cells, this candidate oncogene indeed functions like an oncogene, suggesting a similar role in tumor progression in vivo.</jats:p>",
  "DOI": "10.1073/pnas.91.2.709",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        5,
        31
      ]
    ],
    "date-time": "2006-05-31T12:56:02Z",
    "timestamp": 1149080162000
  },
  "page": "709-713",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 329,
  "title": "Function of a human cyclin gene as an oncogene.",
  "prefix": "10.1073",
  "volume": "91",
  "author": [
    {
      "given": "P W",
      "family": "Hinds",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142."
        }
      ]
    },
    {
      "given": "S F",
      "family": "Dowdy",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142."
        }
      ]
    },
    {
      "given": "E N",
      "family": "Eaton",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142."
        }
      ]
    },
    {
      "given": "A",
      "family": "Arnold",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142."
        }
      ]
    },
    {
      "given": "R A",
      "family": "Weinberg",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142."
        }
      ]
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1994,
        1,
        18
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.91.2.709",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T17:59:10Z",
    "timestamp": 1649872750000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.91.2.709"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        1,
        18
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1994,
          1,
          18
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.91.2.709"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.91.2.709",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1994,
        1,
        18
      ]
    ]
  },
  "assertion": [
    {
      "value": "1994-01-18",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}