DOI: 10.1073/pnas.91.11.5133. Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli.

Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli.

10.1073/pnas.91.11.5133

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A three-dimensional model of M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli, was constructed with the aid of a computer. The modeling process took into account data from chemical and enzymatic protection experiments, phylogenetic analysis, studies of the activities of mutants, and the kinetics of reactions catalyzed by the binding of substrate to M1 RNA. The model provides a plausible picture of the binding to M1 RNA of the tRNA domain of a precursor tRNA substrate. The scissile bond and adjacent segments of the aminoacyl acceptor stem of a precursor tRNA substrate can fit into a cleft that leads to the phylogenetically conserved, central part of the structure.

Bibliography

Westhof, E., & Altman, S. (1994). Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli. Proceedings of the National Academy of Sciences, 91(11), 5133â5137.

Authors 2

E Westhof (first)
S Altman (additional)

References 0 Referenced 56

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:47 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:45 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 7:04 a.m.)
Issued	31 years, 3 months ago (May 24, 1994)
Published	31 years, 3 months ago (May 24, 1994)
Published Online	31 years, 3 months ago (May 24, 1994)
Published Print	31 years, 3 months ago (May 24, 1994)

Funders 0

None

BibTeX

@article{Westhof_1994, title={Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.11.5133}, DOI={10.1073/pnas.91.11.5133}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Westhof, E and Altman, S}, year={1994}, month=may, pages={5133–5137} }

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