DOI: 10.1073/pnas.91.10.4489. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

10.1073/pnas.91.10.4489

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Various first messengers linked to phospholipase C, including acetylcholine and interleukin 1, regulate the production both of the secreted form of the amyloid protein precursor (APP) and of amyloid beta-protein. We have now identified intracellular signals which are responsible for mediating these effects. We show that activation of phospholipase C may affect APP processing by either of two pathways, one involving an increase in protein kinase C and the other an increase in cytoplasmic calcium levels. The effects of calcium on APP processing appear to be independent of protein kinase C activation. The observed effects of calcium on APP processing may be of therapeutic utility.

Bibliography

Buxbaum, J. D., Ruefli, A. A., Parker, C. A., Cypess, A. M., & Greengard, P. (1994). Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proceedings of the National Academy of Sciences, 91(10), 4489â4493.

Authors 5

J D Buxbaum (first)
A A Ruefli (additional)
C A Parker (additional)
A M Cypess (additional)
P Greengard (additional)

References 0 Referenced 132

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:46 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:43 p.m.)
Indexed	1 month, 1 week ago (July 16, 2025, 9:07 a.m.)
Issued	31 years, 3 months ago (May 10, 1994)
Published	31 years, 3 months ago (May 10, 1994)
Published Online	31 years, 3 months ago (May 10, 1994)
Published Print	31 years, 3 months ago (May 10, 1994)

Funders 0

None

BibTeX

@article{Buxbaum_1994, title={Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.}, volume={91}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.91.10.4489}, DOI={10.1073/pnas.91.10.4489}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Buxbaum, J D and Ruefli, A A and Parker, C A and Cypess, A M and Greengard, P}, year={1994}, month=may, pages={4489–4493} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        16
      ]
    ],
    "date-time": "2025-07-16T13:07:18Z",
    "timestamp": 1752671238977
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "10",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1994,
        5,
        10
      ]
    ]
  },
  "abstract": "<jats:p>Various first messengers linked to phospholipase C, including acetylcholine and interleukin 1, regulate the production both of the secreted form of the amyloid protein precursor (APP) and of amyloid beta-protein. We have now identified intracellular signals which are responsible for mediating these effects. We show that activation of phospholipase C may affect APP processing by either of two pathways, one involving an increase in protein kinase C and the other an increase in cytoplasmic calcium levels. The effects of calcium on APP processing appear to be independent of protein kinase C activation. The observed effects of calcium on APP processing may be of therapeutic utility.</jats:p>",
  "DOI": "10.1073/pnas.91.10.4489",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        5,
        31
      ]
    ],
    "date-time": "2006-05-31T12:46:31Z",
    "timestamp": 1149079591000
  },
  "page": "4489-4493",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 132,
  "title": "Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.",
  "prefix": "10.1073",
  "volume": "91",
  "author": [
    {
      "given": "J D",
      "family": "Buxbaum",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "A A",
      "family": "Ruefli",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "C A",
      "family": "Parker",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "A M",
      "family": "Cypess",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "P",
      "family": "Greengard",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021."
        }
      ]
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1994,
        5,
        10
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.91.10.4489",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T17:43:51Z",
    "timestamp": 1649871831000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.91.10.4489"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1994,
        5,
        10
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "10",
    "published-print": {
      "date-parts": [
        [
          1994,
          5,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.91.10.4489"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.91.10.4489",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1994,
        5,
        10
      ]
    ]
  },
  "assertion": [
    {
      "value": "1994-05-10",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}