DOI: 10.1073/pnas.90.7.3024. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

10.1073/pnas.90.7.3024

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The purpose of this study was to investigate the induction of inducible nitric oxide synthase (iNOS) mRNA in the brain tissue of rats and mice under the following experimental conditions: in rats infected with borna disease virus and rabies virus, in mice infected with herpes simplex virus, and in rats after the induction of experimental allergic encephalitis. The results showed that iNOS mRNA, normally nondetectable in the brain, was present in animals after viral infection or after induction of experimental allergic encephalitis. The induction of iNOS mRNA coincided with the severity of clinical signs and in some cases with the presence of inflammatory cells in the brain. The results indicate that nitric oxide produced by cells induced by iNOS may be the toxic factor accounting for cell damage and this may open the door to approaches to the study of the pathogenesis of neurological diseases.

Bibliography

Koprowski, H., Zheng, Y. M., Heber-Katz, E., Fraser, N., Rorke, L., Fu, Z. F., Hanlon, C., & Dietzschold, B. (1993). In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proceedings of the National Academy of Sciences, 90(7), 3024â3027.

Authors 8

H Koprowski (first)
Y M Zheng (additional)
E Heber-Katz (additional)
N Fraser (additional)
L Rorke (additional)
Z F Fu (additional)
C Hanlon (additional)
B Dietzschold (additional)

References 0 Referenced 345

None

Dates

Type	When
Created	19 years, 3 months ago (June 1, 2006, 8:27 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:48 p.m.)
Indexed	3 days, 5 hours ago (Sept. 3, 2025, 6:05 a.m.)
Issued	32 years, 5 months ago (April 1, 1993)
Published	32 years, 5 months ago (April 1, 1993)
Published Online	32 years, 5 months ago (April 1, 1993)
Published Print	32 years, 5 months ago (April 1, 1993)

Funders 0

None

BibTeX

@article{Koprowski_1993, title={In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.7.3024}, DOI={10.1073/pnas.90.7.3024}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Koprowski, H and Zheng, Y M and Heber-Katz, E and Fraser, N and Rorke, L and Fu, Z F and Hanlon, C and Dietzschold, B}, year={1993}, month=apr, pages={3024–3027} }

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