DOI: 10.1073/pnas.90.6.2428. Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

10.1073/pnas.90.6.2428

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The interleukin 2 receptor (IL-2R) consists of at least two subunits, alpha and beta, both of which can bind interleukin 2 (IL-2). Recent studies have demonstrated the existence of a third subunit, a 64-kDa molecule termed IL-2R gamma chain, and have suggested that gamma chain functions to regulate the rate of IL-2 dissociation from the receptor. In the present report we have addressed whether the gamma chain modulates IL-2R affinity by contributing contact sites for IL-2 binding. Using reagents that allow the IL-2R complex to be immunoprecipitated through the IL-2 molecule itself, we demonstrate the existence of a stable IL-2-IL-2R gamma-chain complex. These studies thus establish that the IL-2R gamma chain directly contributes to the IL-2-binding site, consistent with the hypothesis that gamma chain influences IL-2R affinity through its direct interaction with IL-2.

Bibliography

Voss, S. D., Leary, T. P., Sondel, P. M., & Robb, R. J. (1993). Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain. Proceedings of the National Academy of Sciences, 90(6), 2428â2432.

Authors 4

S D Voss (first)
T P Leary (additional)
P M Sondel (additional)
R J Robb (additional)

References 0 Referenced 52

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:41 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:36 p.m.)
Indexed	2 months, 2 weeks ago (June 11, 2025, 4:23 p.m.)
Issued	32 years, 5 months ago (March 15, 1993)
Published	32 years, 5 months ago (March 15, 1993)
Published Online	32 years, 5 months ago (March 15, 1993)
Published Print	32 years, 5 months ago (March 15, 1993)

Funders 0

None

BibTeX

@article{Voss_1993, title={Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.6.2428}, DOI={10.1073/pnas.90.6.2428}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Voss, S D and Leary, T P and Sondel, P M and Robb, R J}, year={1993}, month=mar, pages={2428–2432} }

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