DOI: 10.1073/pnas.90.23.11117. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.

10.1073/pnas.90.23.11117

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Estrogen receptor (ER)-binding fragments were isolated from human genomic DNA by using a recombinant ER protein. Using one of these fragments as a probe, we have identified an estrogen-responsive gene that encodes a putative zinc finger protein. It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp). efp cDNA contains a consensus estrogen-responsive element at the 3' untranslated region that can act as a downstream estrogen-dependent enhancer. Moreover, efp is regulated by estrogen as demonstrated at both the mRNA and the protein level in ER-positive cells derived from mammary gland. These data suggest that efp may represent an estrogen-responsive transcription factor that mediates phenotypic expression of the diverse estrogen action. Thus, the genomic binding-site cloning may be applicable for isolation of the target genes of other transcription factors.

Bibliography

Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H., & Muramatsu, M. (1993). Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. Proceedings of the National Academy of Sciences, 90(23), 11117â11121.

Authors 10

S Inoue (first)
A Orimo (additional)
T Hosoi (additional)
S Kondo (additional)
H Toyoshima (additional)
T Kondo (additional)
A Ikegami (additional)
Y Ouchi (additional)
H Orimo (additional)
M Muramatsu (additional)

References 0 Referenced 119

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:36 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:27 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 14, 2024, 3:12 a.m.)
Issued	31 years, 9 months ago (Dec. 1, 1993)
Published	31 years, 9 months ago (Dec. 1, 1993)
Published Online	31 years, 9 months ago (Dec. 1, 1993)
Published Print	31 years, 9 months ago (Dec. 1, 1993)

Funders 0

None

BibTeX

@article{Inoue_1993, title={Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.23.11117}, DOI={10.1073/pnas.90.23.11117}, number={23}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Inoue, S and Orimo, A and Hosoi, T and Kondo, S and Toyoshima, H and Kondo, T and Ikegami, A and Ouchi, Y and Orimo, H and Muramatsu, M}, year={1993}, month=dec, pages={11117–11121} }

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