DOI: 10.1073/pnas.90.15.7391. Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.

Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.

10.1073/pnas.90.15.7391

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the total colonies formed in culture from fractionated vibrissae were in this location and fewer than 4% were located in the matrix area of the follicle. Finer dissection of the bulge-containing region located the colony-forming cells in the small part containing the bulge itself. The segregation of keratinocyte colony-forming cells in the bulge confirms the hypothesis that the bulge is the reservoir of the stem cells responsible for the long-term growth of the hair follicle and perhaps of the epidermis as well.

Bibliography

Kobayashi, K., Rochat, A., & Barrandon, Y. (1993). Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa. Proceedings of the National Academy of Sciences, 90(15), 7391â7395.

Authors 3

K Kobayashi (first)
A Rochat (additional)
Y Barrandon (additional)

References 0 Referenced 165

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:28 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:27 p.m.)
Indexed	2 months, 1 week ago (June 21, 2025, 2:02 a.m.)
Issued	32 years, 1 month ago (Aug. 1, 1993)
Published	32 years, 1 month ago (Aug. 1, 1993)
Published Online	32 years, 1 month ago (Aug. 1, 1993)
Published Print	32 years, 1 month ago (Aug. 1, 1993)

Funders 0

None

BibTeX

@article{Kobayashi_1993, title={Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.15.7391}, DOI={10.1073/pnas.90.15.7391}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kobayashi, K and Rochat, A and Barrandon, Y}, year={1993}, month=aug, pages={7391–7395} }

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