DOI: 10.1073/pnas.90.14.6439. Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.

10.1073/pnas.90.14.6439

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Development and survival of neurons in the central nervous system are dependent on the activity of a variety of endogenous neurotrophic agents. Using combined isotopic and nonisotopic in situ hybridization histochemistry, we have found that subsets of neurons within the developing forebrain coexpress the mRNAs for both neurotrophins (nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3) and their receptors (p75NGFR, TrkA, and TrkB). The colocalization of mRNA for neurotrophin receptors and their ligands in presumptive neurotrophin target neurons suggests the potential for autocrine and paracrine mechanisms of action during development. Such mechanisms may ensure the onset of differentiation and survival of specific subsets of neurons prior to and following target innervation.

Bibliography

Miranda, R. C., Sohrabji, F., & Toran-Allerand, C. D. (1993). Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proceedings of the National Academy of Sciences, 90(14), 6439â6443.

Authors 3

R C Miranda (first)
F Sohrabji (additional)
C D Toran-Allerand (additional)

References 0 Referenced 194

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:27 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:32 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 2:02 a.m.)
Issued	32 years, 1 month ago (July 15, 1993)
Published	32 years, 1 month ago (July 15, 1993)
Published Online	32 years, 1 month ago (July 15, 1993)
Published Print	32 years, 1 month ago (July 15, 1993)

Funders 0

None

BibTeX

@article{Miranda_1993, title={Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.14.6439}, DOI={10.1073/pnas.90.14.6439}, number={14}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Miranda, R C and Sohrabji, F and Toran-Allerand, C D}, year={1993}, month=jul, pages={6439–6443} }

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