DOI: 10.1073/pnas.90.13.6305. Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

10.1073/pnas.90.13.6305

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The interaction of Fc receptors with antibody-antigen complexes activates multiple biological functions in hematopoietic cells. Recently, protein-tyrosine phosphorylation has been suggested to be involved in Fc receptor-mediated cell signaling. Here we show that the Src-like protein-tyrosine kinase Fgr, which is specifically expressed in mature myelomonocytic cells, coimmunoprecipitates with IgG Fc receptor II (Fc gamma RII), but not with Fc gamma RIII from detergent lysates of human peripheral neutrophils. Crosslinking of Fc gamma RII induced a rapid increase in the tyrosine kinase activity and comodulation of Fgr. These results suggest that Fgr is physically and functionally associated with Fc gamma RII and involved in Fc gamma RII-mediated signal transduction pathways.

Bibliography

Hamada, F., Aoki, M., Akiyama, T., & Toyoshima, K. (1993). Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. Proceedings of the National Academy of Sciences, 90(13), 6305â6309.

Authors 4

F Hamada (first)
M Aoki (additional)
T Akiyama (additional)
K Toyoshima (additional)

References 0 Referenced 91

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:25 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:27 p.m.)
Indexed	5 months ago (March 30, 2025, 10:29 p.m.)
Issued	32 years, 2 months ago (July 1, 1993)
Published	32 years, 2 months ago (July 1, 1993)
Published Online	32 years, 2 months ago (July 1, 1993)
Published Print	32 years, 2 months ago (July 1, 1993)

Funders 0

None

BibTeX

@article{Hamada_1993, title={Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.13.6305}, DOI={10.1073/pnas.90.13.6305}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hamada, F and Aoki, M and Akiyama, T and Toyoshima, K}, year={1993}, month=jul, pages={6305–6309} }

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