Abstract
We have examined the effect of implantation of a supernumerary notochord or floor plate on dorsoventral somitic organization. We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives--i.e., axial muscles and dermis--thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.
Dates
Type | When |
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Created | 19 years, 2 months ago (May 31, 2006, 8:23 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 1:36 p.m.) |
Indexed | 5 days, 5 hours ago (Aug. 23, 2025, 1:02 a.m.) |
Issued | 32 years, 2 months ago (June 1, 1993) |
Published | 32 years, 2 months ago (June 1, 1993) |
Published Online | 32 years, 2 months ago (June 1, 1993) |
Published Print | 32 years, 2 months ago (June 1, 1993) |
@article{Pourqui__1993, title={Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.11.5242}, DOI={10.1073/pnas.90.11.5242}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Pourquié, O and Coltey, M and Teillet, M A and Ordahl, C and Le Douarin, N M}, year={1993}, month=jun, pages={5242–5246} }