DOI: 10.1073/pnas.90.10.4533. bcl-2 inhibits death of central neural cells induced by multiple agents.

bcl-2 inhibits death of central neural cells induced by multiple agents.

10.1073/pnas.90.10.4533

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The protooncogene bcl-2, which has been implicated in B-cell lymphoma development, inhibits apoptosis due to growth factor withdrawal in some, but not all, hematopoietic cells. Recently we found that bcl-2 also inhibits apoptosis in PC12 pheochromocytoma cells. We now report that bcl-2 inhibits the death of a central neural cell line due to serum and growth factor withdrawal, the calcium ionophore A23187, glucose withdrawal, membrane peroxidation, and, in some cases, free radical-induced damage. This broad range of protective effects of BCL-2 protein suggests that BCL-2 may interact with a central step in neural cell death. Measurements of intracellular free calcium suggest that BCL-2 alters the transduction of neural death signals at a point distal to the rise in intracellular free calcium.

Bibliography

Zhong, L. T., Sarafian, T., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H., & Bredesen, D. E. (1993). bcl-2 inhibits death of central neural cells induced by multiple agents. Proceedings of the National Academy of Sciences, 90(10), 4533â4537.

Authors 7

L T Zhong (first)
T Sarafian (additional)
D J Kane (additional)
A C Charles (additional)
S P Mah (additional)
R H Edwards (additional)
D E Bredesen (additional)

References 0 Referenced 450

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:23 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:39 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	32 years, 3 months ago (May 15, 1993)
Published	32 years, 3 months ago (May 15, 1993)
Published Online	32 years, 3 months ago (May 15, 1993)
Published Print	32 years, 3 months ago (May 15, 1993)

Funders 0

None

BibTeX

@article{Zhong_1993, title={bcl-2 inhibits death of central neural cells induced by multiple agents.}, volume={90}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.90.10.4533}, DOI={10.1073/pnas.90.10.4533}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zhong, L T and Sarafian, T and Kane, D J and Charles, A C and Mah, S P and Edwards, R H and Bredesen, D E}, year={1993}, month=may, pages={4533–4537} }

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