DOI: 10.1073/pnas.89.7.3060. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

10.1073/pnas.89.7.3060

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.

Bibliography

Ip, N. Y., IbÃ¡Ã±ez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., Le Beau, M. M., Espinosa, R., & Squinto, S. P. (1992). Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proceedings of the National Academy of Sciences, 89(7), 3060â3064.

Authors 10

N Y Ip (first)
C F Ibáñez (additional)
S H Nye (additional)
J McClain (additional)
P F Jones (additional)
D R Gies (additional)
L Belluscio (additional)
M M Le Beau (additional)
R Espinosa (additional)
S P Squinto (additional)

References 0 Referenced 399

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:18 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:46 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:48 p.m.)
Issued	33 years, 5 months ago (April 1, 1992)
Published	33 years, 5 months ago (April 1, 1992)
Published Online	33 years, 5 months ago (April 1, 1992)
Published Print	33 years, 5 months ago (April 1, 1992)

Funders 0

None

BibTeX

@article{Ip_1992, title={Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.7.3060}, DOI={10.1073/pnas.89.7.3060}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ip, N Y and Ibáñez, C F and Nye, S H and McClain, J and Jones, P F and Gies, D R and Belluscio, L and Le Beau, M M and Espinosa, R and Squinto, S P}, year={1992}, month=apr, pages={3060–3064} }

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